PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Compute standard Non-Compartmental Analysis (NCA) parameters for typical pharmacokinetic analyses and summarize them.

Version: 0.10.2
Imports: checkmate, dplyr (≥ 0.5.0), digest, nlme, purrr, rlang, stats, tidyr, tibble, utils
Suggests: covr, cowplot, ggplot2, knitr, labeling, pander, pmxTools, rmarkdown, spelling, testthat (≥ 3.0.0), units, withr
Published: 2023-04-29
Author: Bill Denney ORCID iD [aut, cre], Clare Buckeridge [aut], Sridhar Duvvuri [ctb]
Maintainer: Bill Denney <wdenney at>
License: AGPL-3
NeedsCompilation: no
Language: en-US
Citation: PKNCA citation info
Materials: README NEWS
In views: MixedModels, Pharmacokinetics
CRAN checks: PKNCA results


Reference manual: PKNCA.pdf
Vignettes: Introduction to PKNCA and Usage Instructions
Computing NCA Parameters for Theophylline
Selection of Calculation Intervals
Sparse NCA Calculations
AUC Calculation with PKNCA
Half-Life Calculation
Unit Assignment and Conversion with PKNCA
Data Imputation
Superposition of Pharmacokinetic Data
Methods Used for Dose-Aware Concentration Interpolation/Extrapolation
Noncompartmental evaluation of time to steady-state
PKNCA Training Sessions
Options for Controlling PKNCA
PKNCA Validation
Writing PKNCA Parameter Functions


Package source: PKNCA_0.10.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): PKNCA_0.10.2.tgz, r-oldrel (arm64): PKNCA_0.10.2.tgz, r-release (x86_64): PKNCA_0.10.2.tgz, r-oldrel (x86_64): PKNCA_0.10.2.tgz
Old sources: PKNCA archive

Reverse dependencies:

Reverse depends: respirometry
Reverse imports: pmxTools, ruminate, ubiquity
Reverse suggests: babelmixr2


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