This article is a brief illustration of how to use
`do_mc()`

from the package manymome (Cheung & Cheung,
2023) to generate Monte Carlo estimates for
`indirect_effect()`

and `cond_indirect_effects()`

to form Monte Carlo confidence intervals.

Although `indirect_effect()`

and
`cond_indirect_effects()`

can also be used to generate Monte
Carlo estimates when they are called (see
`vignette("manymome")`

), there may be situations in which
users prefer generating the Monte Carlo estimates first before calling
`indirect_effect()`

and `cond_indirect_effects()`

.
`do_mc()`

is for this purpose.

Monte Carlo confidence intervals only support models fitted by
`lavaan::sem()`

and (since version 0.1.9.8)
`semTools::sem.mi()`

or `semTools::runMI()`

.

The function `do_mc()`

retrieves the variance-covariance
matrix of the parameter estimates and then generates a number of sets of
simulated sample estimates using a multivariate normal distribution.
Other parameters and implied variances, covariances, and means of
variables are then generated from these simulated estimates.

When a \((1 - \alpha)\)% Monte Carlo
confidence interval is requested, the \(100(\alpha/2)\)^{th} percentile and
the \(100(1 - \alpha/2)\)^{th}
percentile are used to form the confidence interval. For a 95% Monte
Carlo confidence interval, the 2.5^{th} percentile and
97.5^{th} percentile will be used.

The following workflow will be demonstrated;

Fit the model as usual.

Use

`do_mc()`

to generate the Monte Carlo estimates.Call other functions (e.g,

`indirect_effect()`

and`cond_indirect_effects()`

) to compute the desired effects and form Monte Carlo confidence intervals.

`lavaan::sem()`

The data set for illustration:

```
library(manymome)
<- data_med
dat head(dat)
#> x m y c1 c2
#> 1 9.931992 17.89644 20.73893 1.426513 6.103290
#> 2 8.331493 17.92150 22.91594 2.940388 3.832698
#> 3 10.327471 17.83178 22.14201 3.012678 5.770532
#> 4 11.196969 20.01750 25.05038 3.120056 4.654931
#> 5 11.887811 22.08645 28.47312 4.440018 3.959033
#> 6 8.198297 16.95198 20.73549 2.495083 3.763712
```

It has one predictor (`x`

), one mediator (`m`

),
one outcome variable (`y`

), and two control variables
(`c1`

and `c2`

).

The following simple mediation model with two control variables
(`c1`

and `c2`

) will be fitted:

Fit the model by `lavaan::sem()`

:

```
<-
mod "
m ~ x + c1 + c2
y ~ m + x + c1 + c2
"
<- sem(model = mod, data = dat,
fit_lavaan fixed.x = FALSE,
estimator = "MLR")
summary(fit_lavaan)
#> lavaan 0.6.16 ended normally after 1 iteration
#>
#> Estimator ML
#> Optimization method NLMINB
#> Number of model parameters 15
#>
#> Number of observations 100
#>
#> Model Test User Model:
#> Standard Scaled
#> Test Statistic 0.000 0.000
#> Degrees of freedom 0 0
#>
#> Parameter Estimates:
#>
#> Standard errors Sandwich
#> Information bread Observed
#> Observed information based on Hessian
#>
#> Regressions:
#> Estimate Std.Err z-value P(>|z|)
#> m ~
#> x 0.935 0.075 12.437 0.000
#> c1 0.198 0.079 2.507 0.012
#> c2 -0.168 0.099 -1.703 0.089
#> y ~
#> m 0.785 0.233 3.363 0.001
#> x 0.508 0.323 1.573 0.116
#> c1 0.140 0.188 0.747 0.455
#> c2 -0.154 0.214 -0.720 0.471
#>
#> Covariances:
#> Estimate Std.Err z-value P(>|z|)
#> x ~~
#> c1 0.026 0.121 0.211 0.833
#> c2 0.100 0.084 1.186 0.235
#> c1 ~~
#> c2 -0.092 0.109 -0.841 0.400
#>
#> Variances:
#> Estimate Std.Err z-value P(>|z|)
#> .m 0.681 0.085 7.976 0.000
#> .y 4.030 0.580 6.944 0.000
#> x 1.102 0.150 7.338 0.000
#> c1 1.218 0.161 7.540 0.000
#> c2 0.685 0.073 9.340 0.000
```

Suppose we would like to use robust “sandwich” standard errors and
confidence intervals provided by MLR for the free parameters, but want
to use Monte Carlo confidence interval for the indirect effect. In the
call above, we used `estimator = "MLR"`

and did not set
`se = "boot"`

.

We can then call `do_mc()`

on the output of
`lavaan::sem()`

to generate the Monte Carlo estimates of all
free parameters *and* the implied statistics, such as the
variances of `m`

and `y`

, which are not free
parameters but are needed to form the confidence interval of the
*standardized* indirect effect.

```
<- do_mc(fit = fit_lavaan,
mc_out_lavaan R = 10000,
seed = 4234)
#> Stage 1: Simulate estimates
#> Stage 2: Compute implied statistics
```

Usually, just three arguments are needed:

`fit`

: The output of`lavaan::sem()`

.`R`

: The number of Monte Carlo replications. Should be at least 10000 in real research.`seed`

: The seed for the random number generator. To be used by`set.seed()`

. It is recommended to set this argument such that the results are reproducible.

Parallel processing is not used. However, the time taken is rarely long because there is no need to refit the model many times.

`do_mc()`

in Other Functions of `manymome`

When calling `indirect_effect()`

or
`cond_indirect_effects()`

, the argument `mc_out`

can be assigned the output of `do_mc()`

. They will then
retrieve the stored simulated estimates to form the Monte Carlo
confidence intervals, if requested.

```
<- indirect_effect(x = "x",
out_lavaan y = "y",
m = "m",
fit = fit_lavaan,
mc_ci = TRUE,
mc_out = mc_out_lavaan)
out_lavaan#>
#> == Indirect Effect ==
#>
#> Path: x -> m -> y
#> Indirect Effect 0.733
#> 95.0% Monte Carlo CI: [0.301 to 1.180]
#>
#> Computation Formula:
#> (b.m~x)*(b.y~m)
#> Computation:
#> (0.93469)*(0.78469)
#>
#> Monte Carlo confidence interval with 10000 replications.
#>
#> Coefficients of Component Paths:
#> Path Coefficient
#> m~x 0.935
#> y~m 0.785
```

Reusing the simulated estimates can ensure that all analyses with Monte Carlo confidence intervals are based on the same set of simulated estimates, without the need to generate these estimates again.

Monte Carlo confidence intervals can be formed when the
variance-covariance matrix of the parameter estimates can be retrieved.
Therefore, `do_mc()`

can be used when missing data is handled
by full information maximum likelihood in `lavaan`

using
`missing = "fiml"`

. It also supports multiple imputation if
`semTools::sem.mi()`

or `semTools::runMI()`

(since
version 0.1.9.8). See `vignette("do_mc_lavaan_mi")`

for an
illustration.

The output of `do_mc()`

in this case is an object of the
class `mc_out`

, which is a list of `R`

lists, each
with two elements: `est`

and `implied_stats`

.

This is the content of `est`

of the first list:

```
1]]$est
mc_out_lavaan[[#> lhs op rhs est
#> 1 m ~ x 0.909
#> 2 m ~ c1 0.198
#> 3 m ~ c2 -0.163
#> 4 y ~ m 0.641
#> 5 y ~ x 0.921
#> 6 y ~ c1 0.010
#> 7 y ~ c2 0.141
#> 8 m ~~ m 0.641
#> 9 y ~~ y 3.432
#> 10 x ~~ x 1.023
#> 11 x ~~ c1 0.074
#> 12 x ~~ c2 0.028
#> 13 c1 ~~ c1 1.180
#> 14 c1 ~~ c2 -0.261
#> 15 c2 ~~ c2 0.718
```

The content is just the first four columns of the output of
`lavaan::parameterEstimates()`

. Note that only fixed and free
parameters are used so other rows, if any, are not used even if
present.

This is the content of `implied_stats`

of the first
list:

```
1]]$implied_stats
mc_out_lavaan[[#> $cov
#> m y x c1 c2
#> m 1.586
#> y 1.864 6.059
#> x 0.939 1.548 1.023
#> c1 0.344 0.263 0.074 1.180
#> c2 -0.143 0.033 0.028 -0.261 0.718
#>
#> $mean
#> m y x c1 c2
#> NA NA NA NA NA
```

It has three elements. `cov`

is the implied variances and
covariances of all variables. If a model has latent variables, they will
be included too. The other elements, `mean`

and
`mean_lv`

, are the implied means of the observed variables
and the latent variables (if any), respectively. The elements are
`NA`

if mean structure is not in the fitted model.

Monte Carlo confidence intervals require the variance-covariance
matrix of all free parameters. Therefore, only models fitted by
`lavaan::sem()`

and (since 0.1.9.8)
`semTools::sem.mi()`

or `semTools::runMI()`

are
supported. Models fitted by `stats::lm()`

do not have a
variance-covariance matrix for the regression coefficients from two or
more regression models and so are not supported by
`do_mc()`

.

For further information on `do_mc()`

, please refer to its
help page.

Cheung, S. F., & Cheung, S.-H. (2023). *manymome*: An R
package for computing the indirect effects, conditional effects, and
conditional indirect effects, standardized or unstandardized, and their
bootstrap confidence intervals, in many (though not all) models.
*Behavior Research Methods*. https://doi.org/10.3758/s13428-023-02224-z