tci: Target Controlled Infusion (TCI)

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Version: 0.2.0
Depends: R (≥ 3.6.0)
Imports: ggplot2, stats, utils, truncnorm, mvtnorm, gridExtra, reshape, reshape2, xtable, Rcpp, knitr
LinkingTo: Rcpp, RcppArmadillo
Suggests: testthat (≥ 2.1.0), rmarkdown, mrgsolve
Published: 2022-08-15
DOI: 10.32614/
Author: Ryan Jarrett [aut, cre]
Maintainer: Ryan Jarrett <ryantjarrett at>
License: GPL-2
NeedsCompilation: yes
Materials: README
CRAN checks: tci results


Reference manual: tci.pdf
Vignettes: Custom PK models and algorithms
Introduction to tci package
Population PK models


Package source: tci_0.2.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): tci_0.2.0.tgz, r-oldrel (arm64): tci_0.2.0.tgz, r-release (x86_64): tci_0.2.0.tgz, r-oldrel (x86_64): tci_0.2.0.tgz
Old sources: tci archive


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